The CTN is led by senior investigators committed to improving the lives of individuals with Lyme and other tick-borne diseases. The focus is treatment, as this is a major clinical need and a much neglected area. The CTN studies will help to shape medical practice in the United States and elsewhere, as its study results will be published in prominent peer-reviewed journals.

This research however is not possible without the generous participation of the patient community. We thank all study participants as they play such a vital role in this major public health endeavor!

Treatment research can be of different types. Some treatments are “open-label” meaning that the treatment is known by participant and doctor. Some are “double-masked” meaning that neither participant nor doctor knows whether the participant is receiving one medicine, another medicine, or an inactive drug (‘placebo’). Studies generally vary in duration from 2 -6 months. All studies are conducted under IRB-approved protocols and all participants are carefully monitored for safety and clinical outcome. The public can learn more about current Lyme and other Tick-borne disease treatment studies by going to Just type in the name of the tick-borne disease and you will find a list of current and completed studies.

Active Clinical Studies

As new studies are approved and launched, we will post them here with contact information. Should you wish to learn about any of the current studies underway at the CTN nodes, please go to their specific webpage:

Columbia University Lyme and Tick-Borne Diseases Research Center

Johns Hopkins Lyme Disease Research Center

Children's National Division of Infectious Diseases