In recognition of a severe unmet need, the Steven & Alexandra Cohen Foundation’s grant to Columbia University established the first national Columbia Clinical Trials Network Coordinating Center (CTNCC) for Lyme and Other Tick-borne Diseases. Under the leadership of Dr. Brian Fallon, this Clinical Trials Coordinating Center aims to propel national research toward the goal of identifying more effective treatments for patients with Lyme and other tick-borne diseases.

Providing oversight to ensure that the highest-quality clinical trials are undertaken, the CTN Coordinating Center at Columbia will provide funding support for small pilot studies, assist investigators in protocol design and statistical research planning, establish and manage a national case registry, and create a data management system for multi-site clinical trials. The clinical trials network will be a powerful engine to drive large-scale clinical trials and potentially transformational early-stage research.



The Columbia CTN is happy to announce the following pilot study awards:


  • Tetracycline treatment tolerability trial for PTLD
  • Vagus nerve stimulation for persistent fatigue


  • Mast cell treatment in post-tick bite illness (PTBI)
  • Proteolytic enzymes as potential treatments for fibrin/amyloid deposition and platelet hyperactivation in Lyme Disease
  • Pulse IV ceftriaxone therapy for patients with persistent symptoms in Lyme disease

To learn more about these studies, go to Active Clinical Studies


Thanks to everyone who participated in our 2021 request for suggestions on treatment for TBD!

We received 104 suggestions. The suggestions varied widely. Some contributors recommended more than one approach to treatment. Your suggestions were not limited to treatment ideas: almost 30% described a diagnostic tool that could be used in TBD research. Many suggestions described intriguing cases and patient histories. Treatment research ideas described antibiotics, non-pharmacological types of treatment, and herbal treatment including diets and nutrition suggestions.

Your input is an invaluable way for our CTN Coordinating Center team to learn about novel treatment approaches that may improve the care of individuals with Lyme and other tick-borne diseases.