In recognition of a severe unmet need, the Steven & Alexandra Cohen Foundation’s grant to Columbia University established the first national
Columbia Clinical Trials Network Coordinating Center (CTNCC) for Lyme and Other Tick-borne Diseases. Under the leadership of Dr. Brian Fallon,
this Clinical Trials Coordinating Center aims to propel national research toward the goal of identifying more effective treatments for patients
with Lyme and other tick-borne diseases.
Providing oversight to ensure that the highest-quality clinical trials are undertaken, the CTN Coordinating Center at Columbia will provide funding
support for small pilot studies, assist investigators in protocol design and statistical research planning, establish and manage a national case
registry, and create a data management system for multi-site clinical trials. The clinical trials network will be a powerful engine to drive large-scale
clinical trials and potentially transformational early-stage research.
More...
CTN Patient Registry Launched
We are happy to announce the launch of the CTN patient registry. This case registry will assist researchers in identifying
potential candidates for current or upcoming research studies carried out by the Lyme Clinical Trials Network. Additionally,
it enables us to provide you with news and updates on ongoing clinical research.
To learn more or to join the registry please click here.
The Columbia CTN is happy to announce the following pilot study awards:
2021
- Tetracycline treatment tolerability trial for PTLD
- Vagus nerve stimulation for persistent fatigue
2022
- Transcranial direct current stimulation and cognitive retraining for Lyme brain fog
- Early neurodevelopmental outcomes of exposure to Lyme in pregnancy
2023
- Mast cell treatment in post-tick bite illness (PTBI)
- Proteolytic enzymes as potential treatments for fibrin/amyloid deposition and platelet hyperactivation in Lyme Disease
- Pulse IV ceftriaxone therapy for patients with persistent symptoms in Lyme disease
To learn more about these studies, go to Active Clinical Studies
To learn more about the elements of clinical trials research that are of interest to patients, a survey was conducted
in the fall of 2023. This survey aimed to provide insight into what types of studies prospective participants would
be interested in. The findings from this survey would aim to inform future communications and strategies pertaining
to patient recruitment for investigators conducting clinical trials on Lyme and other Tick-borne diseases.
More...