BACKGROUND

In recognition of a severe unmet need, the Steven & Alexandra Cohen Foundation’s grant to Columbia University established the first national Columbia Clinical Trials Network Coordinating Center (CTNCC) for Lyme and Other Tick-borne Diseases. Under the leadership of Dr. Brian Fallon, this Clinical Trials Coordinating Center aims to propel national research toward the goal of identifying more effective treatments for patients with Lyme and other tick-borne diseases.

Providing oversight to ensure that the highest-quality clinical trials are undertaken, the CTN Coordinating Center at Columbia will provide funding support for small pilot studies, assist investigators in protocol design and statistical research planning, establish and manage a national case registry, and create a data management system for multi-site clinical trials. The clinical trials network will be a powerful engine to drive large-scale clinical trials and potentially transformational early-stage research.

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LATEST NEWS

The Columbia CTN is happy to announce the following pilot study awards:

2021

  • Tetracycline treatment tolerability trial for PTLD
  • Vagus nerve stimulation for persistent fatigue

2022

  • Transcranial direct current stimulation and cognitive retraining for Lyme brain fog
  • Early neurodevelopmental outcomes of exposure to Lyme in pregnancy

2023

  • Mast cell treatment in post-tick bite illness (PTBI)
  • Proteolytic enzymes as potential treatments for fibrin/amyloid deposition and platelet hyperactivation in Lyme Disease
  • Pulse IV ceftriaxone therapy for patients with persistent symptoms in Lyme disease

To learn more about these studies, go to Active Clinical Studies

FOR PATIENTS

To learn more about the elements of clinical trials research that are of interest to patients, a survey was conducted in the fall of 2023. This survey aimed to provide insight into what types of studies prospective participants would be interested in. The findings from this survey would aim to inform future communications and strategies pertaining to patient recruitment for investigators conducting clinical trials on Lyme and other Tick-borne diseases.

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